Tuberculosis Drug Resistance Detection Array Kit

The Tuberculosis Drug Resistance Detection Array Kit can detect 14 of the most frequently found mutations in three genes which are associated with resistance to the two most important (first- line) anti-tuberculosis drugs,rifampicin, and isoniazid.

OVERVIEW

Tuberculosis (TB) remains one of the main threats to humans, causing 8 million new cases and 2 million deaths each year. The problem is becoming more critical with the emergence and spread of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, defined as resistant to at least isoniazid (INH) and rifampin (RFP). About 2 to 3% of all new TB cases worldwide are due to MDR strain, and the highest MDR populations among new cases have been found in China (11%) and eastern Europe (7 to 14%).
China is not only one of the 22 high-burden countries that collectively accounts for ca. 80% of the world’s TB cases, but it is also the hotspot area of very high prevalence of MDR TB identified by the World Health Organization. Because of the very large financial implications of the treatment and spread of MDR strains due to globalization, MDR TB has been classified as a global pandemic more deadly than AIDS, with the potential to destabilize society.
* Drug-resistant TB emerges as a result of treatment mismanagement, and is passed from person to person in the same way as drug-sensitive TB.